Guzek won the Midwest Collegiate League Pitcher of the Week award twice over the first three weeks of the 2019 MCL season before being shut down for the summer by his collegiate coaches in order to report to school early and begin preparation for his first season with the Hawkeyes. Guzek started three games and totaled 17 innings with the Oilmen, pitching at least into the sixth on each occasion. He racked up 26 strikeouts against six walks while yielding 15 hits and posting a 3.18 ERA.

Guzek played his high school ball at Brother Rice in Chicago before joining the Indiana State baseball team as a freshman in 2018. He sat out that year while recovering from an injury, then transferred to Gulf Coast State College for 2019. Guzek appeared in three games this season at Iowa and did not yield an earned run while striking out five and permitting two hits over 3 1/3 innings before the season was shortened due to COVID-19. He is rated as the 30th-best MLB Prospect in the Big Ten by D1Baseball.com.